Multivalent import platform(MVIP)Multivalent import platform(MVIP)Fully independent intellectual property rights. Kylonova's Multivalent Import Platform (MVIP) is a specific delivery system for hepatic disease treatments constructed using the hepatic parenchymal cells of the Asialoglycoprotein receptor (ASGPR). General Formula: (X-L)n-B-D-T Wherein: ※ X is a target-specific ligand ※ L is a branch of a sterically stabilized structure ※ B is a connector ※ D is a linker ※ T is a drug ※ n is an integer from 1 to 15
Multivalent Import Platform (MVIP) has the following features: ● It has been applied to siRNA drugs. Pre-clinical subcutaneous injection test has been finished. It has active liver targeting, stability and good biodegradability. ● Applicable to small molecule drugs, the pre-clinical intestinal drug administration has been verified, which can avoid the whole-body intake of drugs and reduce the toxic side effects on other organs. ● Low production costs, can be produced in bulk, and sold commercially. |